| A genetic variant linked to human longevityMutations in genes involved in the insulin/IGF-1 signaling pathway (IIS) improve longevity in animal models, but there is minimal evidence that mutations in human homologues of genes in this pathway are associated with a long-lived phenotype. In order to find such evidence, one could take a traditional forward genetics approach and examine populations of centenarians. A new study in elderly Japanese men has done just that -- and has revealed that a common variant in a human homolog of an IIS pathway gene is associated with increased longevity. |
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