Aging interventions in rodents and humans don't always work the same way
Biogerontologists have learned a lot about the mechanisms of aging by studying "model organisms" -- shorter-lived animals that are experimentally tractable -- and extrapolating those results to humans. This is generally an effective strategy but it doesn't always work. A new study, on the mechanisms of calorie restriction in regulating age-controlling hormones, reminds us that we can't always assume that results obtained in rodent studies will hold true in humans.
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