| Comparing calorie restriction for weight loss vs. CR for longevityAs we know, a calorie restriction (CR) diet improves the health and lifespan in animal models. In the ongoing search for human biomarkers to assess the effects of CR in humans, Crujeiras et al. analyzed sirtuin gene expression changes and blood antioxidant markers in obese patients who followed a 30% calorie restricted diet for 8 weeks. Overall, patients had a significant reduction in body weight, BMI, fat mass and cholesterol but showed no significant changes in glucose, triglycerides, insulin or insulin resistance (It’s possible that if these patients had maintained a CR diet for a longer period of time, significant changes would have been noted.) Total antioxidant capacity (AOP) and nitric oxide levels were significantly increased, and glutathione peroxidase was significantly decreased, indicating an improvement in the oxidative stress response. |
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