| A transcriptional "switch" that controls the longevity vs. reproduction decisionThe insulin-like growth factor (IGF) pathway is one of the longest-known and well-studied regulators of longevity. Activation of these upstream kinases results in inactivation of the longevity assurance gene DAF-16, which encodes a transcription factor that activates stress resistance genes. A new study demonstrates that DAF-16 also downregulates transcription of the upstream kinases, reinforcing the decision to devote resources to maintenance and repair instead of reproduction. |
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